A friend of mine stumbled onto this site the other day, and the concept is pure genious. It’s called http://www.howstuffworks.com/, and it will give you the answers to everything from How Kryptonite Works to How Lock Picking Works. However, my favorite entry concerns my favorite show, “Lost”.
According to the article, How the DHARMA Initiative Works (Careful, there are spoilers), the numbers actually coorespond to the world coordinate system. If you plug the numbers 4 8 15 16 23 42…actually “4.815 162.342″…into Google Maps, it displays a point in the ocean northeast of Australia and southwest of the Marshall Islands.
Try it out here. You may need to zoom out a little to see it.